产品货号：
Z33658
中文名称：
SCAP抗体(N-term)
英文名称：
Anti-SCAP Antibody(N-term)(Clone#1992C245.37.16)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SCAP Antibody (N-term) (Clone#1992C245.37.16) |
| 指标别名 | Sterol regulatory element-binding protein cleavage-activating protein,SCAP,SREBP cleavage-activating protein,SCAP,KIAA0199 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | SCAP |
| 克隆号 | 1992C245.37.16 |
| 抗体来源 | Mouse |
| 免疫原 | This SCAP antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 49-83 amino acids from the N-terminal region of human SCAP. |
| 计算分子量 | 140kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Escort protein required for cholesterol as well as lipid homeostasis.Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol.Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER.Low sterol concentrations trigger release of INSIG,a conformational change in the SSC domain of SCAP,unmasking of the ER export signal,recruitment into COPII-coated vesicles,transport to the Golgi complex,proteolytic cleavage of SREBF in the Golgi,release of the transcription factor fragment of SREBF from the membrane,its import into the nucleus and up-regulation of LDLR,INSIG1 and the mevalonate pathway (By similarity). |
| Uniprot ID | Q12770 |
相关搜索：SCAP抗体(N-term)，SCAP单抗，Anti-SCAP Antibody(N-term)(Clone#1992C245.37.16)